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Ion channels underlie a broad range of the most basic biological processes, from excitation and signaling to secretion and absorption. Like enzymes, they are diverse and ubiquitous macromolecular catalysts with high substrate specificity and subject to strong regulation. This fully revised and expanded Third Edition of Ion Channels of Excitable Membranes describes the known channels and their physiological functions, then develops the conceptual background needed to understand their architecture and molecular mechanisms of operation. It includes new chapters on calcium signaling, structural biology, and molecular biology and genomics. Ion Channels of Excitable Membranes begins with the classical biophysical work of Hodgkin and Huxley, continues with the roles of channels in cellular signaling, then develops the physical and molecular principles needed for explaining permeation, gating, pharmacological modification, and molecular diversity, and ends with a discussion of channel evolution. Ion Channels of Excitable Membranes is written to be accessible and interesting to life scientists and physical scientists of all kinds. It introduces all the concepts that a graduate student should be aware of but is also effective in advanced undergraduate courses. It has long been the recognized authoritative overview of this field used by all neuroscientists.

• Sales Rank: #432887 in Books
• Published on: 2001-07-16
• Original language: English
• Number of items: 1
• Dimensions: 9.50" h x 7.25" w x 1.25" l, 3.36 pounds
• Binding: Hardcover
• 814 pages

Features

• electrophysiology
• plasma membrane biophysics
• complex interplay of ionic channels
• models of single channels

Review
"Earlier versions were notable achievements for their clarity and broad utility. The third edition is markedly expanded, remarkably up to date, and stands as an unmitigated tour de force. Complete and enthusiastic, but not overwhelming, the text builds intuitively from the biophysical roots of the discipline. By maintaining a historical flavor, the reader is cleanly offered the essential ideas and concepts that remain key even as the field evolves. The book . . . remains a resource for practitioners of the craft and the essential guide to the electrophysiological universe." --Steven A. N. Goldstein, Cell

About the Author
BERTIL HILLE teaches at the University of Washington. He won the 1999 Albert Lasker Award.

Most helpful customer reviews

8 of 9 people found the following review helpful.
A classic. Still authoritative.
By Jihwan Myung
This is an authoritative textbook on ion channels that is often quoted in numerous textbooks in neurophysiology. Hille himself has contributed a lot in this field. The Hogkin-Huxley model is the de facto standard model in neurophysiology but certain things about neurons cannot be explained only with voltage-controlled sodium and potassium channels. With the patch-clamp technique, we have found a way to explore other interesting channles. To remind you, there are a world of ion channels! Hille's textbook show there are indeed a variety of channels most of which are poorly understood. As a reviewer below has commented, it also gives a unique insight into the history of neural membrane research. Concepts are explained with clearity. Details measurement techniques.

30 of 36 people found the following review helpful.
Destined to become an Oprah Book Club selection
By Syn Apse
Some books have opening sentences that grab you in an instant. "Call me Ishmael." "It was the best of times, it was the worst of times." And now, Hille joins the list of authors to reach out and grab us, with the awe-inspiring "Ion channels are macromolecular pores in cell membranes."

Even after my fifth reading, that line still gives me the shivers.

But it takes more than a brilliant opening to make a great book, and Hille delivers. From a distinctly jaunty derivation of the Nernst equation to the page-turning thrills of non-stationary fluctuation analysis, the book is hard to put down. It does bog down a little in Chapter 10, "Elementary Properties of Ions in Solution"--after all, is there anyone who isn't already aware of the fundamentals of electrodiffusion? But this is really a minor trifle in an otherwise masterful work.

It's just a matter of time before Oprah gives this book a nod; buy it now and avoid the rush!

2 of 2 people found the following review helpful.
A staple of electrophysiology
By Tricia A. Hardt
If you are interested in the science of electrophysiology, this is your textbook. Starts with basic, ground concepts and works it way up. Begin with an intro of Ohm's law, etc. and the history of electrophysiology and moves to more in depth material for each ion channel. The only drawback is that this is the most up to date version, so there has been some progress since then. But for anyone involved in patch clamping, this is a must read.

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[X595.Ebook] PDF Ebook The Great Hunt (The Wheel of Time, Book 2), by Robert Jordan

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The Wheel of Time turns and Ages come and pass. What was, what will be, and what is, may yet fall under the Shadow. For centuries, gleemen have told of The Great Hunt of the Horn. Now the Horn itself is found: the Horn of Valere long thought only legend, the Horn which will raise the dead heroes of the ages.

And it is stolen.

• Sales Rank: #17426 in Books
• Brand: Wheel of Time Novels & Books
• Published on: 1991-10-15
• Released on: 1991-10-15
• Original language: English
• Number of items: 1
• Dimensions: 6.76" h x 1.57" w x 4.23" l, .70 pounds
• Binding: Mass Market Paperback
• 705 pages

Features

• Great product!

From Library Journal
Chosen by fate to become the Dragon Reborn--savior and destroyer of his world--young Rand al'Thor attempts to outrun his destiny by joining in a mad search for the lost Horn of Valere. Continuing the story begun in The Eye of the World ( LJ 2/15/90), Jordan creates a lush, sprawling tapestry of a novel in the tradition of Tolkien and Eddings. Recommended where fantasy is popular.
Copyright 1990 Reed Business Information, Inc.

Review

“Jordan has come to dominate the world that Tolkien began to reveal.... The battle scenes have the breathless urgency of firsthand experience, and the ... evil laced into the forces of good, the dangers latent in any promised salvation, the sense of the unavoidable onslaught of unpredictable events bear the marks of American national experience during the last three decades.” ―Edward Rothstein, The New York Times

“Those who like fantasy can rejoice. This is the genuine article ... characters you can care about, a world you can believe in, hideous monsters, battles, magic, even love.... I only have one problem. How am I going to get by until the next volume comes out?” ―John Lee, author of The Unicorn Solution

“Rousing, slam-bang ... full of valiant skirmishes, great heroes, and close rescues. The real war is only beginning, but this one battle at least ends with the sort of grand finale worth re-reading a time or two.” ―Locus

From the Back Cover

The Wheel of Time turns and Ages come and pass. What was, what will be, and what is, may yet fall under the Shadow. For centuries, gleemen have told of The Great Hunt of the Horn. Now the Horn itself is found: the Horn of Valere long thought only legend, the Horn which will raise the dead heroes of the ages.

And it is stolen.

THE WHEEL OF TIME

Book One: The Eye of the World
Book Two: The Great Hunt
Book Three: The Dragon Reborn
Book Four: The Shadow Rising
Book Five: The Fires of Heaven
Book Six: Lord of Chaos
Book Seven: A Crown of Swords
Book Eight: The Path of Daggers
Book Nine: Winter's Heart
Book Ten: Crossroads of Twilight

Most helpful customer reviews

0 of 0 people found the following review helpful.
Can't do women characters well, but still worth reading in doses
By marialuisa
I really do like high fantasy and Robert Jordan created a universe, replete with a fully thought out magic system that works. No, I don't think that he's anywhere near the writer Tolkien was, but he is pretty darn good. That being said, he has a really difficult time with creating women characters. I get tired of the pettiness he writes into them over the slightest thing. The completely pointless snotty attitude that Nynaeve gives to Moraine (and pretty much all the other women) makes me want to slap her. We have this great myth in our culture that women cannot get along with each other. Usually it's posed as an issue over competition for a male. And the myth is perpetuated by insecure men who really don't know much about and who feel threatened by women. Each of the three male protagonists has an internal dialogue about how women are "different", "think strangely" etc. Is there some other reason he keeps making us seem so bitchy? I'm pretty tired of both of the two poses that he gives the women too: standing with their arms crossed under their breasts and standing with fists planted on their hips. Neither one is too attractive. I really, really want to like this series more than I think I do. I'm in the fourth book of the series though and it's definitely time for a break. Jordan is a competent writer and has moments that are close to excellence but they fade. In the context of the universe that he created though, the books are an enjoyable if not great to read. If you can go and give it a break for a bit and go back to it, it probably works better than if you read straight through and live in the universe that The Wheel of Time for a while. After the fourth volume, I'm out of it for a while. Good for escapist beach reading. since I live in Hawaii, that works for me, so long as I get past the shallow female characters he devises.

0 of 0 people found the following review helpful.
If you liked the first novel in this series you will enjoy ...
By Casey
If you liked the first novel in this series you will enjoy this book. As with the rest of the series, just stick with it and try not to predict anything of the characters! (I suffered from expecting way too much of the characters.) I highly recommend purchasing an audible version of this novel because they are long books and the pace can be slow. Much more enjoyable if listening to extended parts of the book.

1 of 1 people found the following review helpful.
One intense hunting trip
By High Fantasy Reader
Slightly shorter than Eye of the World, but slightly faster paced, the Great Hunt matches the bar set by the original and drives the story forward.

The two things about the Wheel of Time that I enjoy the most are probably the characterization and the worldbuilding. The various cultures and lands are well-fleshed out, and Jordan develops every place that the heroes stop by on the adventure. Shienar was an excellent example, along with Tar Valon. The characters are at a high caliber, the writing is well-done and descriptive, the story is excellent, the plot is slightly tighter than the first book, and Jordan manages to incorporate some of the grit of real life without turning this into an R-rated book. . . .Though I admit it would probably have been better if he had. ;)

Minor bits of goodness mixed in include: The concept of the Heron-mark is cool, the characters' magical powers actually progress over time (I wish Terry Goodkind had copied THIS part instead of ripping off the Aes Sedai), the plot is complex and requires intelligence to keep up with, no ham-handed messages or foreshadowing, realistic take on learning and using swordplay, and some definite moments of hilarity.

Sad to say, there are still a couple of problems. Some of the characters are starting to get on my nerves, particularly Nynaeve, who never develops out of her two-dimensional role. Egwene is working her way up there, too, though she's not very annoying compared to Nynaeve.I'd also like to know what strange problem is inducing the female characters to "sniff" every few chapters.

The plot is good most of the time. There are a few definite places where it moves along a bit slowly, though it is an improvement from the first book. I have the same problem with the Wheel of Time that I do with the latter books of a Song of Ice and Fire; there are too many damn chapters where we're taken away from the action and getting into the heads of random people along the way. If an author does this, then we should at least be taken right into some tense excitement somewhere. I don't really care about Bayle Domon mulling things over while gloating over his cuendillar collection, or some exotic goons from across the sea arriving to take over villages and make them swear oaths of loyalty. Can we get back to Egwene/Elayne at the White Tower and Rand/Mat/Perrin hunting the Horn, please? The plot is wonderfully structured and engaging and all, with a better resolution than the first book, but that sometimes makes the interruptions all the more annoying.

The Great Hunt is at times frustrating, but patience is rewarded with a good storyline and characters. A solid 4 stars out of five.

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• Sales Rank: #7145440 in Books
• Published on: 1800
• Binding: Paperback

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This new edition of the Manual is comprehensively updated to include the 2011, 2012 and 2013 World Championship winning Red Bull cars (the original book covers the 2010 RB6). In particular, the 'Anatomy' chapter, which includes details of developments introduced since the original book was published in June 2011, including KERS, DRS, developments due to rule changes concerning 'blown' diffusers, and the switch from Bridgestone to Pirelli tyres, as well as the change to 1.6-litre V6 turbocharged engines and the hybrid ERS (Energy Recovery System) introduced for the 2014 season.

• Sales Rank: #714993 in Books
• Published on: 2015-12-01
• Original language: English
• Number of items: 1
• Dimensions: 11.00" h x .75" w x 8.50" l, 2.04 pounds
• Binding: Hardcover
• 200 pages

About the Author
Steve Rendle has worked for Haynes Publishing for 20 years, first as a technical author of car manuals and now as an editor, managing the publication of a wide range of car-related books.

Most helpful customer reviews

1 of 1 people found the following review helpful.
Best explanation of current F1 technology
By Gianfranco Sciacero
Best book on current F1 design, testing, and racing a F1 machine. Excellent!

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Great detail
By M. Ekenja
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Five Stars
By Confidential
Great book!

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Comprehensive textbook for die casting engineers. Provides basic procedures for reducing scrap and controlling defects; identifies 22 types of die casting defects with photomicrographs of each; provides technical details of causes and formation mechanisms of each; suggests solutions to correct each type of defect.

• Sales Rank: #115660 in eBooks
• Published on: 2013-06-12
• Released on: 2013-06-12
• Format: Kindle eBook

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Second Opinion: An Introduction to Health Sociology introduces students to the theories, concepts, issues, and contexts of the field.

Features

* Vignettes at the beginning of each chapter introduce a topic and encourage a sociologically reflexive approach

* "Doing Health Sociology" boxes link theory to practice and highlight sociological research and theories for informing health care practice, health policy, and public understanding of the social origins of health and illness

* Discussion questions at the end of each chapter facilitate student engagement and continue the sociological debate

* Extensive online resources supplement each chapter, including YouTube and MOOC videos, suggested further reading, recommended websites, and chapters from previous editions

• Sales Rank: #1508136 in Books
• Published on: 2013-12-30
• Original language: English
• Number of items: 1
• Dimensions: 8.30" h x 1.10" w x 10.80" l, .0 pounds
• Binding: Paperback
• 608 pages

About the Author

John Germov is Professor of Sociology and Pro Vice-Chancellor of the Faculty of Education and Arts at the University of Newcastle in Australia.

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[A197.Ebook] Ebook Free Nuclear Cardiology Review: A Self-Assessment Tool, by Wael A. Jaber MD FACC FAHA, Manuel D. Cerqueira MD FACC FASNC

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Employing a question and answer style format, Nuclear Cardiology Review prepares you for the certification exam of Nuclear Cardiology .  Nuclear Cardiology Review has over 200 questions covering nuclear imaging basic sciences, maintenance of safety and quality, study interpretation and appropriately applying test results for accurately diagnosing and managing patients.  Other sections include physics, artifacts, prognostic data, anomalies, and non-coronary testing. Test questions are annotated with discussion on image interpretation and technical aspects that may lead to image artifacts.

Features

• 200 questions and answers that duplicate the breakdown of the CBNC test
• Questions on noncoronary use of SPECT
• Procedural planning questions to test your knowledge
• Prepared by respected Cleveland Clinic staff

 

Plus, you have access to a free companion website with questions and answers so you have access anytime, anywhere.

• Sales Rank: #33391 in Books
• Brand: Brand: Lippincott Williams Wilkins
• Published on: 2012-08-29
• Original language: English
• Dimensions: 11.25" h x 8.50" w x .25" l, 1.27 pounds
• Binding: Paperback
• 200 pages

Features

• Used Book in Good Condition

Review
"This is a good review of the field of nuclear cardiology. It is probably most useful for practitioners who have some knowledge of the field, including trainees with some knowledge of the field, but less useful for trainees who are just being initially exposed to it. Overall, it is a very useful review."

Bennett S. Greenspan, MD, MS (Medical College of Georgia)
Doody's Reviews (March, 2013)

Weighted Numerical Score: 97 - 5 Stars!

Most helpful customer reviews

2 of 2 people found the following review helpful.
good but needs improvement
By riversbed
This book is very useful in highlighting some of the facts which were overlooked during the nuclear board review course. I encountered many questions from the book during the board exam. I used the kindle version of the book. There are two disadvantages I would like to point out. 1) Choices for multiple choice questions are assigned numbers such as 1,2,3, and 4. But answers are given in letters A, B,C or D. It is not a major issue 2) Answers are given at the end of the chapter. It is quite frustrating to go back and forth between the questions and answers in the kindle. I request authors to pay attention to this and place the answers next to the individual question. I was able to overcome this situation by using two devices at the same time.

0 of 0 people found the following review helpful.
Great questions with explanations...more than just image interpretation.
By Daniel J Wale
Although this a question book, the explanations are very detailed and can be used as a primary text. I am radiology trained and therefore found the book more skewed towards a cardiologists perspective (which I liked). The book is VERY heavy on techniques, indications, and pharmacology regarding performing stress tests.

3 of 3 people found the following review helpful.
Excellent for nuclear board review.
By RAUL ALONSO
I am a cardiology fellowship program director. I strongly recommend this book as a review for the nuclear boards. But please remember to study all of the nuclear guidelines also.

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